5Alpha-Cholestan-3Beta-Ol-6-One

5Alpha-Cholestan-3Beta-Ol-6-One

SCHEMBL248174

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC(=O)C4CC(O)CC[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1L1 Q9UHC9 5/20 1.00
USP2 O75604 4/20 1.00
LMNA P02545 3/20 1.00
RORC P51449 3/20 0.59
OSBP P22059 2/20 0.59
OSBP2 Q969R2 2/20 0.59
ABCB1 P08183 1/20 0.59
CYP46A1 Q9Y6A2 1/20 0.59
ALDH1A1 P00352 1/20 0.59
MAPT P10636 1/20 0.59
RORA P35398 3/20 0.57
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
ALOX15 P16050 1/20 0.57
TP53 P04637 1/20 0.56
FNTA P49354 1/20 0.56
FNTB P49356 1/20 0.56
CDC25A P30304 1/20 0.55
GPR183 P32249 1/20 0.54
GPBAR1 Q8TDU6 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
5Alpha-Cholestan-3Beta-Ol-6-One SCHEMBL26653578 1.00 NPC1L1 (1.00) NPC1L1USP2LMNARORCOSBP
5Alpha-Cholestan-3Beta-Ol-6-One SCHEMBL26653575 1.00 NPC1L1 (1.00) NPC1L1USP2LMNARORCOSBP
5Alpha-Cholestan-3Beta-Ol-6-One SCHEMBL4276094 1.00 NPC1L1 (1.00) NPC1L1USP2LMNARORCOSBP
5Alpha-Cholestan-3Beta-Ol-6-One SCHEMBL18407109 1.00 NPC1L1 (1.00) NPC1L1USP2LMNARORCOSBP
5Alpha-Cholestan-3Beta-Ol-6-One SCHEMBL12430811 1.00 NPC1L1 (1.00) NPC1L1USP2LMNARORCOSBP
5Alpha-Cholestan-3Beta-Ol-6-One SCHEMBL14420788 1.00 NPC1L1 (1.00) NPC1L1USP2LMNARORCOSBP
5Alpha-Cholestan-3Beta-Ol-6-One SCHEMBL5341515 1.00 NPC1L1 (1.00) NPC1L1USP2LMNARORCOSBP
5Alpha-Cholestan-3Beta-Ol-6-One SCHEMBL13429389 1.00 NPC1L1 (1.00) NPC1L1USP2LMNARORCOSBP
5Alpha-Cholestan-3Beta-Ol-6-One SCHEMBL14898038 1.00 NPC1L1 (1.00) NPC1L1USP2LMNARORCOSBP
5Alpha-Cholestan-3Beta-Ol-6-One SCHEMBL7996326 0.98 NPC1L1 (0.96) NPC1L1USP2LMNARORCOSBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 972 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062716-A1 LIPID NANOPARTICLE (LNP) COMPOSITION OR FORMULATION FOR NUCLEIC ACID THERAPEUTICS POPVAX PRIVATE LTD (IN) 2026-03-05 US claimed
EP-4577196-A1 LIPID NANOPARTICLE (LNP) COMPOSITION OR FORMULATION FOR NUCLEIC ACID THERAPEUTICS Popvax Private Limited (IN) 2025-07-02 EP claimed
WO-2025052180-A2 LIPIDS AND LIPID NANOPARTICLES Axelyf ehf. (IS) 2025-03-13 WO claimed
WO-2024044178-A1 LIPID NANOPARTICLE (LNP) COMPOSITION OR FORMULATION FOR NUCLEIC ACID THERAPEUTICS POPVAX PRIVATE LIMITED (IN) 2024-02-29 WO claimed
EP-3368024-B1 COMPOSITIONS COMPRISING CANNABIDIOL AND SECOND THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER AKOS BIOSCIENCES INC (US) 2023-09-20 EP claimed
US-20230003721-A1 MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2023-01-05 US claimed
US-20220054429-A1 COMPOSITIONS COMPRISING CANNABIDIOL AND SECOND THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER AKOS BIOSCIENCES, INC. 2022-02-24 US claimed
EP-2411052-B1 CARRIER COMPRISING A VITAMIN E DERIVATIVE AND ANNEXIN V UCL BUSINESS LTD (GB) 2020-10-07 EP claimed
US-20180311182-A1 COMPOSITIONS COMPRISING CANNABIDIOL AND SECOND THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER AKOS BIOSCIENCES, INC. 2018-11-01 US claimed
EP-3368024-A1 COMPOSITIONS COMPRISING CANNABIDIOL AND SECOND THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER Jay Pharma, Inc. (CA) 2018-09-05 EP claimed
US-9566310-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2017-02-14 US claimed
US-20170027961-A1 COMPOSITIONS FOR THE TREATMENT OF CATARACTS Catacore, Inc. (US) 2017-02-02 US claimed
US-9545392-B2 Carrier comprising a vitamin E derivative UCL BUSINESS PLC (GB) 2017-01-17 US claimed
US-20160244761-A1 LIPID PARTICLES WITH ASYMMETRIC CATIONIC LIPIDS FOR RNA DELIVERY ARCTURUS THERAPEUTICS, INC. 2016-08-25 US claimed
US-20150290276-A1 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY 2015-10-15 US claimed
US-20140072536-A1 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA (US) 2014-03-13 US claimed
US-20120115771-A1 CARRIER UCL BUSINESS PLC (GB) 2012-05-10 US claimed
EP-2411052-A2 CARRIER COMPRISING A VITAMIN E DERIVATIVE UCL Business PLC (GB) 2012-02-01 EP claimed
WO-2010109212-A2 CARRIER UCL BUSINESS PLC (GB) 2010-09-30 WO claimed
US-RE30538-E VITAMIN D3 DERIVATIVE WHICH PROMOTES INTESTINAL CALCIUM TRANSPORT AND BONE CALCIUM MOBILIZATION WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1981-03-03 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150290276-A1 METHODS OF TREATING MUSCULAR DYSTROPHY ITGB7, ITGA2B, ITGB1 NPC1L1 4043/4885USP2 3097/4885LMNA 484/4885
US-20170027961-A1 COMPOSITIONS FOR THE TREATMENT OF CATARACTS CYP46A1, DHCR7, NR1H3 NPC1L1 69/4885USP2 3111/4885LMNA 769/4885
US-20140072536-A1 METHODS OF TREATING MUSCULAR DYSTROPHY ITGB7, ITGA2B, ITGB1 NPC1L1 4043/4885USP2 3097/4885LMNA 484/4885
US-20260062716-A1 LIPID NANOPARTICLE (LNP) COMPOSITION OR FORMULATION FOR NUCLEIC ACID THERAPEUTICS CETP, PLTP, LDLR NPC1L1 5/4885USP2 3448/4885LMNA 123/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.