SCHEMBL24818663

SCHEMBL24818663

Cn1cnnc1-c1cc(F)ccc1-c1cccc(-c2nc3cc(CN4CC[C@@H](C#N)C4)cc(C(F)(F)F)c3o2)c1

nearest known ligand 0.40

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 20/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24819884 0.90 PDCD1 (0.43) CBLB
SCHEMBL24822059 0.90 PDCD1 (0.43) CBLB
SCHEMBL24818755 0.89 GRM2 (0.38) CBLB
SCHEMBL24818829 0.88 CBLB (0.42) CBLB
SCHEMBL24818946 0.87 PDCD1 (0.39) CBLB
SCHEMBL24820117 0.87 HRH1 (0.41) CBLB
SCHEMBL24820104 0.87 HRH1 (0.41) CBLB
SCHEMBL30152972 0.87 HRH1 (0.41) CBLB
SCHEMBL24818393 0.87 HRH1 (0.41) CBLB
SCHEMBL24819893 0.87 CBLB (0.40) CBLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4359381-A1 CBL-B MODULATORS AND USES THEREOF Nimbus Clio, Inc. (US) 2024-05-01 — — EP disclosed
CN-117858865-A CBL-B modulators and uses thereof 林伯士克莱奥公司 2024-04-09 — — CN disclosed
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed
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