Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CBLB | Q13191 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 4/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30152749 | 0.90 | CBLB (0.43) | CBLBSCN9AMAPTTP53HSD11B1 | |
| SCHEMBL24819869 | 0.90 | CBLB (0.43) | CBLBSCN9AMAPTTP53HSD11B1 | |
| SCHEMBL30153127 | 0.89 | S1PR1 (0.37) | CBLBCETPSCN9AESR1ESR2 | |
| SCHEMBL24819786 | 0.89 | S1PR1 (0.37) | CBLBCETPSCN9AESR1ESR2 | |
| SCHEMBL30153156 | 0.88 | CETP (0.39) | CBLBCETPSCN9AMAPTTP53 | |
| SCHEMBL30153254 | 0.88 | CBLB (0.37) | NPC1RAB9ACBLBCETPSCN9A | |
| SCHEMBL24819872 | 0.88 | CETP (0.39) | CBLBCETPSCN9AMAPTTP53 | |
| SCHEMBL24820501 | 0.88 | CBLB (0.37) | NPC1RAB9ACBLBCETPSCN9A | |
| SCHEMBL24818728 | 0.87 | SCN9A (0.38) | CBLBCETPSCN9AMAPTTP53 | |
| SCHEMBL30153353 | 0.87 | SCN9A (0.38) | CBLBCETPSCN9AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |