Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 3/20 | 0.48 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 3/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27085990 | 0.87 | CBLB (0.52) | CBLBADORA2AADORA2B | |
| SCHEMBL27085904 | 0.86 | CBLB (0.41) | CBLBBDKRB2PDE2A | |
| SCHEMBL29920812 | 0.86 | CBLB (0.43) | CBLBBDKRB2 | |
| SCHEMBL24818748 | 0.86 | CBLB (0.43) | CBLBBDKRB2 | |
| SCHEMBL27085815 | 0.84 | CBLB (0.47) | CBLBBDKRB2PDE2AADORA2A | |
| SCHEMBL30956963 | 0.83 | CBLB (0.42) | CBLBBDKRB2 | |
| SCHEMBL27308766 | 0.83 | CBLB (0.42) | CBLBBDKRB2 | |
| SCHEMBL30792198 | 0.79 | CBLB (0.40) | CBLBPDE2A | |
| SCHEMBL24818633 | 0.77 | CBLB (0.42) | CBLBPDE2APRMT5WDR77 | |
| SCHEMBL30153041 | 0.77 | CBLB (0.42) | CBLBPDE2APRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4602028-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2025-08-20 | — | — | EP | disclosed |
| CN-118791465-A | Cbl-b inhibitors | 北京诺诚健华医药科技有限公司 | 2024-10-18 | — | — | CN | disclosed |
| WO-2024212941-A1 | CBL-B INHIBITOR | 北京诺诚健华医药科技有限公司 | 2024-10-17 | — | — | WO | disclosed |
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| WO-2024081311-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2024-04-18 | — | — | WO | disclosed |
| WO-2024081311-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2024-04-18 | — | — | WO | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-117858707-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| EP-4319756-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022217276-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-10-13 | — | — | WO | disclosed |