Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31397312 | 1.00 | SMARCA2 (0.44) | SMARCA2SMARCA4PBRM1GPR119ADAMTS5 | |
| SCHEMBL31397506 | 0.82 | SMARCA2 (0.44) | SMARCA2SMARCA4PBRM1GPR119ADAMTS5 | |
| SCHEMBL24821049 | 0.82 | SMARCA2 (0.44) | SMARCA2SMARCA4PBRM1GPR119ADAMTS5 | |
| SCHEMBL25337018 | 0.78 | GPR119 (0.41) | GPR119ADAMTS5 | |
| SCHEMBL31236084 | 0.77 | USP30 (0.37) | SMARCA2SMARCA4PBRM1GPR119SETD7 | |
| SCHEMBL26131612 | 0.77 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1GPR119ADAMTS5 | |
| SCHEMBL26129909 | 0.77 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1GPR119ADAMTS5 | |
| SCHEMBL26129911 | 0.77 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1GPR119ADAMTS5 | |
| SCHEMBL25339852 | 0.75 | CNR1 (0.41) | GPR119ADAMTS5 | |
| SCHEMBL31397473 | 0.74 | DDB1 (0.42) | SMARCA2SMARCA4PBRM1GPR119ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271727-A1 | DEGRADER COMPOUNDS AND USES THEREOF | CALICO LIFE SCIENCES LLC (US) | 2022-12-29 | — | — | WO | disclosed |