Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24819650 | 0.87 | CRBN (0.48) | ALDH1A1NPC1HPGDUSP2MAPT | |
| SCHEMBL24819636 | 0.85 | KCNA5 (0.47) | ALDH1A1NPC1HPGDUSP2HRH3 | |
| SCHEMBL31355778 | 0.85 | CHRNA7 (0.48) | ALDH1A1MEN1KMT2A | |
| SCHEMBL24821083 | 0.85 | CRBN (0.52) | ALDH1A1KDM4ENPC1HPGDUSP2 | |
| SCHEMBL24530625 | 0.82 | CRBN (0.42) | ALDH1A1NPC1HPGDUSP2GSPT1 | |
| SCHEMBL30828415 | 0.82 | CRBN (0.55) | POLBGSPT1DDB1CRBN | |
| SCHEMBL31356173 | 0.81 | TNF (0.58) | ALDH1A1KDM4ENPC1HPGDMEN1 | |
| SCHEMBL30828444 | 0.81 | CRBN (0.55) | NPC1MEN1KMT2APOLBRAB9A | |
| SCHEMBL30828446 | 0.81 | CRBN (0.57) | ALDH1A1NPC1HTTPOLBRAB9A | |
| SCHEMBL27411381 | 0.81 | CRBN (0.57) | POLBGSPT1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022272074-A1 | CEREBLON BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2022-12-29 | — | — | WO | disclosed |