Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520213 | 0.90 | MAPT (0.54) | ADRB1SIRT6MAPTKMT2AMEN1 | |
| SCHEMBL2483651 | 0.84 | MAPT (0.48) | ADRB1SIRT6MAPTKMT2AMEN1 | |
| SCHEMBL12006741 | 0.79 | MEN1 (0.63) | ADRB1SIRT6MAPTKMT2AMEN1 | |
| SCHEMBL12005434 | 0.79 | MEN1 (0.63) | ADRB1SIRT6MAPTKMT2AMEN1 | |
| SCHEMBL12005432 | 0.79 | MEN1 (0.63) | ADRB1SIRT6MAPTKMT2AMEN1 | |
| SCHEMBL17888637 | 0.79 | AKR1C3 (0.56) | ADRB1SIRT6MAPTKMT2AMEN1 | |
| SCHEMBL520818 | 0.77 | LMNA (0.63) | ADRB1SIRT6MAPTKMT2AMEN1 | |
| SCHEMBL30984773 | 0.77 | MEN1 (0.64) | ADRB1SIRT6MAPTKMT2AMEN1 | |
| SCHEMBL15552714 | 0.76 | KMT2A (0.55) | ADRB1SIRT6MAPTKMT2AMEN1 | |
| SCHEMBL17645059 | 0.76 | KMT2A (0.55) | ADRB1SIRT6MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |