Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30152879 | 1.00 | HPGD (0.37) | HPGDCLK1SMN1; SMN2VSIRIDO1 | |
| SCHEMBL30153089 | 0.91 | HPGD (0.39) | HPGDCLK1SMN1; SMN2VSIRLMNA | |
| SCHEMBL24821906 | 0.91 | HPGD (0.39) | HPGDCLK1SMN1; SMN2VSIRLMNA | |
| SCHEMBL24820047 | 0.91 | HPGD (0.45) | HPGDCLK1SMN1; SMN2VSIRLMNA | |
| SCHEMBL30152937 | 0.89 | LMNA (0.39) | HPGDCLK1SMN1; SMN2VSIRLMNA | |
| SCHEMBL30153217 | 0.89 | HPGD (0.38) | HPGDCLK1SMN1; SMN2VSIRLMNA | |
| SCHEMBL24820660 | 0.89 | HPGD (0.38) | HPGDCLK1SMN1; SMN2VSIRLMNA | |
| SCHEMBL24818876 | 0.89 | CLK1 (0.43) | HPGDCLK1SMN1; SMN2VSIRLMNA | |
| SCHEMBL24820726 | 0.89 | LMNA (0.39) | HPGDCLK1SMN1; SMN2VSIRLMNA | |
| SCHEMBL24821895 | 0.88 | HPGD (0.37) | HPGDCLK1SMN1; SMN2VSIRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |