Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 20/20 | 0.63 |
| ▸ | CRBN | Q96SW2 | 20/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | IL1B | P01584 | 1/20 | 0.45 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24819409 | 0.86 | DDB1 (0.58) | DDB1CRBN | |
| SCHEMBL20845725 | 0.81 | DDB1 (0.69) | DDB1CRBNIKZF3 | |
| SCHEMBL20845661 | 0.79 | CRBN (0.72) | DDB1CRBNIKZF3 | |
| SCHEMBL21946258 | 0.79 | CRBN (0.72) | DDB1CRBNIKZF3 | |
| SCHEMBL23945499 | 0.79 | CRBN (0.72) | DDB1CRBNIKZF3 | |
| SCHEMBL24029813 | 0.79 | CRBN (0.72) | DDB1CRBNIKZF3 | |
| SCHEMBL20812356 | 0.78 | CRBN (1.00) | DDB1CRBNIKZF3 | |
| SCHEMBL23806542 | 0.78 | CRBN (1.00) | DDB1CRBNIKZF3 | |
| SCHEMBL23806009 | 0.78 | CRBN (1.00) | DDB1CRBNIKZF3 | |
| SCHEMBL31397145 | 0.78 | DDB1 (0.50) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112692-A1 | CASITAS B-LINEAGE LYMPHOMA PROTOONCOGENE B (CBL-B) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |
| WO-2022271727-A1 | DEGRADER COMPOUNDS AND USES THEREOF | CALICO LIFE SCIENCES LLC (US) | 2022-12-29 | — | — | WO | disclosed |