Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 6/20 | 0.54 |
| ▸ | BCL2 | P10415 | 4/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1283572 | 0.87 | AGER (0.69) | AGERMCHR1 | |
| SCHEMBL1283418 | 0.80 | AGER (0.68) | AGERMCHR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3546003 | 0.76 | AGER (0.74) | AGERLMNA | |
| SCHEMBL1577018 | 0.72 | AGER (0.75) | AGERKDM4E | |
| SCHEMBL1889350 | 0.71 | AGER (0.72) | AGERHPGD | |
| SCHEMBL1576905 | 0.71 | AGER (0.72) | AGERHPGD | |
| SCHEMBL1576892 | 0.71 | AGER (0.72) | AGERHPGD | |
| Hydrochloric Acid SCHEMBL1888277 | 0.71 | AGER (0.73) | AGERKDM4E | |
| Hydrochloric Acid SCHEMBL1889808 | 0.71 | AGER (0.73) | AGERKDM4E | |
| Hydrochloric Acid SCHEMBL1889347 | 0.71 | AGER (0.71) | AGERHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482931-B1 | MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE | TRANSTECH PHARMA INC (US) | 2011-10-19 | — | — | EP | claimed |