Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.59 |
| ▸ | PTGES | O14684 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.30 |
| ▸ | PDE2A | O00408 | 4/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15753949 | 0.99 | TRPM8 (0.60) | TRPM8PTGESKDM4ESCN9AP2RX7 | |
| SCHEMBL2482537 | 0.98 | TRPM8 (0.59) | TRPM8PTGESKDM4ESCN9AP2RX7 | |
| SCHEMBL2486018 | 0.93 | TRPM8 (0.50) | TRPM8KDM4ESCN9APDE10APDE2A | |
| SCHEMBL2448318 | 0.92 | TRPM8 (0.51) | TRPM8KDM4ESCN9APDE10APDE2A | |
| SCHEMBL2486020 | 0.91 | TRPM8 (0.50) | TRPM8KDM4ESCN9APDE10APDE2A | |
| SCHEMBL2485363 | 0.90 | TRPM8 (0.48) | TRPM8KDM4ESCN9APOLBNPSR1 | |
| SCHEMBL2483336 | 0.90 | TRPM8 (0.63) | TRPM8PTGESKDM4EL3MBTL1GAA | |
| SCHEMBL2448441 | 0.90 | TRPM8 (0.49) | TRPM8KDM4ESCN9APOLBNPSR1 | |
| SCHEMBL2485365 | 0.89 | TRPM8 (0.48) | TRPM8KDM4ESCN9APOLBNPSR1 | |
| SCHEMBL2452068 | 0.88 | TRPM8 (0.73) | TRPM8PTGESKDM4EL3MBTL1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542552-B1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-15 | — | — | EP | disclosed |
| EP-2542552-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011109587-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-09 | — | — | WO | disclosed |