Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.38 |
| ▸ | WNT3A | P56704 | 4/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 5/20 | 0.36 |
| ▸ | EPM2A | O95278 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1602147 | 0.72 | HTR1D (0.40) | SLC6A4SLC6A2CYP2A6CTNNB1WNT3A | |
| SCHEMBL1465387 | 0.72 | SLC6A2 (0.43) | SLC6A4SLC6A2CYP2A6CTNNB1WNT3A | |
| SCHEMBL13365170 | 0.71 | SLC6A2 (0.45) | SLC6A4SLC6A2CYP2A6CTNNB1WNT3A | |
| SCHEMBL17656346 | 0.71 | SLC6A2 (0.48) | SLC6A4SLC6A2CYP2A6CTNNB1WNT3A | |
| SCHEMBL15069387 | 0.68 | SLC6A2 (0.43) | SLC6A4SLC6A2CYP2A6CTNNB1WNT3A | |
| SCHEMBL1116496 | 0.67 | CA12 (0.55) | CYP2A6CTNNB1WNT3ADYRK1ACDK9 | |
| SCHEMBL19594984 | 0.67 | CTNNB1 (0.40) | SLC6A4SLC6A2CTNNB1WNT3ASLC6A3 | |
| SCHEMBL29240315 | 0.67 | MEN1 (0.49) | SLC6A4SLC6A2CYP2A6CTNNB1WNT3A | |
| SCHEMBL28064573 | 0.66 | SLC6A2 (0.41) | SLC6A4SLC6A2CYP2A6CTNNB1WNT3A | |
| SCHEMBL10878340 | 0.66 | SLC6A4 (0.69) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230127655-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-04-27 | — | — | US | disclosed |
| US-20220411410-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2022-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411410-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | SLC6A4 384/4885SLC6A2 347/4885CYP2A6 1094/4885 |
| US-20230127655-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | SLC6A4 384/4885SLC6A2 347/4885CYP2A6 1094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.