Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylprednisolone Hemisuccinate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.81 |
| ▸ | PGR | P06401 | 4/20 | 0.81 |
| ▸ | AR | P10275 | 2/20 | 0.81 |
| ▸ | F2 | P00734 | 1/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | IL6 | P05231 | 1/20 | 0.52 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.52 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.52 |
| ▸ | GLUL | P15104 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylprednisolone Hemisuccinate SCHEMBL7915 | 1.00 | NR3C1 (1.00) | NR3C1CYP3A4PGRARF2 | |
| Methylprednisolone Hemisuccinate SCHEMBL29053159 | 0.99 | NR3C1 (0.98) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL10400906 | 0.95 | NR3C1 (0.91) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL14867434 | 0.95 | NR3C1 (0.90) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL14867431 | 0.95 | NR3C1 (0.90) | NR3C1CYP3A4PGRARF2 | |
| Methylprednisolone Hemisuccinate SCHEMBL1169509 | 0.92 | NR3C1 (0.85) | NR3C1CYP3A4PGRARF2 | |
| Methylprednisolone Hemisuccinate SCHEMBL10953512 | 0.92 | NR3C1 (0.85) | NR3C1CYP3A4PGRARF2 | |
| Methylprednisolone Hemisuccinate SCHEMBL40947 | 0.92 | NR3C1 (0.85) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL10910221 | 0.92 | NR3C1 (0.85) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL11044631 | 0.91 | NR3C1 (0.84) | NR3C1CYP3A4PGRARF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108366-B1 | Idebenone for the treatment of respiratory illness in muscular dystrophy | SANTHERA PHARMACEUTICALS CH (CH) | 2011-10-19 | — | — | EP | claimed |
| EP-0217287-B1 | [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)-oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts | MERCK & CO. INC. (US) | 1991-06-26 | — | — | EP | disclosed |
| US-4835313-A | BRAIN AND NERVOUS SYSTEM DISORDERS; EDEMA | MERCK & CO., INC. (US) | 1989-05-30 | — | — | US | disclosed |
| US-4797391-A | TREATMENT OF TRAUMA TO THE BRAIN | MERCK & CO., INC. (US) | 1989-01-10 | — | — | US | disclosed |
| US-4782073-A | BRAIN EDEMA | MERCK & CO., INC. (US) | 1988-11-01 | — | — | US | disclosed |
| US-4777281-A | ANTIEDEMIC AGENTS; BRAIN INJURIES | MERCK & CO., INC. (US) | 1988-10-11 | — | — | US | disclosed |
| US-4775695-A | TREATMENT OF BRAIN INJURIES AND EDEMA | MERCK & CO., INC. (US) | 1988-10-04 | — | — | US | disclosed |
| US-4771076-A | TREATMENT OF BRAIN INJURY AND EDEMA | MERCK & CO., INC. (US) | 1988-09-13 | — | — | US | disclosed |
| US-4769370-A | BRAIN INJURY TREATMENT | MERCK & CO., INC. (US) | 1988-09-06 | — | — | US | disclosed |
| US-4754061-A | TREATMENT OF BRAIN INJURY | MERCK & CO., INC. (US) | 1988-06-28 | — | — | US | disclosed |
| US-4605663-A | BRAIN TRAUMA | MERCK & CO., INC. (US) | 1986-08-12 | — | — | US | disclosed |
| US-4604403-A | Use of substituted-3(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones for treating grey matter edema | MERCK & CO., INC. (US) | 1986-08-05 | — | — | US | disclosed |
| US-4604396-A | TREATMENT OF GREY MATTER EDEMAS | MERCK & CO., INC. (US) | 1986-08-05 | — | — | US | disclosed |
| US-4596821-A | Brain disorders | MERCK & CO., INC. (US) | 1986-06-24 | — | — | US | disclosed |
| US-4579869-A | BRAIN INJURIES, ANTIISCHEMIC AGENTS | MERCK & CO., INC. (US) | 1986-04-01 | — | — | US | disclosed |
| US-4356313-A | [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid esters and their analogs, the parent acids and their salts | MERCK & CO., INC. (US) | 1982-10-26 | — | — | US | disclosed |
| US-4356314-A | [5,6,9A-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives | MERCK & CO., INC. (US) | 1982-10-26 | — | — | US | disclosed |
| US-4337354-A | BRAIN AND SPINAL CHORD DAMAGE | MERCK & CO., INC. (US) | 1982-06-29 | — | — | US | disclosed |
| US-4317922-A | [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives | MERCK & CO., INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4316043-A | ANTIEDEMIC AGENTS | MERCK & CO., INC. (US) | 1982-02-16 | — | — | US | disclosed |