SCHEMBL248268

SCHEMBL248268

C=C[CH]N1CCCC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4556830 1.00
SCHEMBL4556846 0.97
SCHEMBL2081256 0.97
SCHEMBL4556501 0.97
SCHEMBL168922 0.97
SCHEMBL4557090 0.93
SCHEMBL409268 0.93
SCHEMBL414445 0.86
SCHEMBL4557221 0.77 CXCR4 (0.33)
SCHEMBL5508323 0.75 KMT2A (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 403 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023217764-A1 NOX INHIBITORS FOR USE IN THE TREATMENT OF ALPORT SYNDROME CALLIDITAS THERAPEUTICS SUISSE SA (CH) 2023-11-16 WO claimed
US-20210177811-A1 USE OF NOX INHIBITORS FOR TREATMENT OF CANCER CALLIDITAS THERAPEUTICS SUISSE SA (CH) 2021-06-17 US claimed
EP-3703747-A1 USE OF NOX INHIBITORS FOR TREATMENT OF CANCER GenKyoTex Suisse SA (CH) 2020-09-09 EP claimed
EP-3479843-A1 USE OF NOX INHIBITORS FOR TREATMENT OF CANCER GenKyoTex Suisse SA (CH) 2019-05-08 EP claimed
CN-105121436-B New pyridine derivate 豪夫迈·罗氏有限公司 2018-07-27 CN claimed
CN-108026046-A SUBSTITUTED QUINAZOLINE COMPOUNDS AND THEIR USE AS INHIBITORS OF G12C MUTANT KRAS, HRAS AND/OR NRAS PROTEINS 亚瑞克西斯制药公司 2018-05-11 CN claimed
CN-105121436-A Novel pyridine derivatives HOFFMANN LA ROCHE 2015-12-02 CN claimed
CN-105061422-A Pyrazolo pyridine derivatives as NADPH oxidase inhibitors GENKYOTEX S A 2015-11-18 CN claimed
EP-2190291-B1 HSP90 INHIBITORS WITH MODIFIED TOXICITY UNIV COLORADO REGENTS (US) 2015-10-14 EP claimed
US-9073919-B2 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors GENKYOTEX SA (CH) 2015-07-07 US claimed
US-20020156080-A1 Method for treating glaucoma IIIB ALTEON, INC. 2002-10-24 US claimed
WO-2002076975-A1 CHEMICAL DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT AVENTIS PHARMA S.A. (FR) 2002-10-03 WO claimed
WO-2002053162-A1 METHOD FOR TREATING GLAUCOMA IIIB ALTEON, INC. (US) 2002-07-11 WO claimed
EP-0790986-B1 ANILINE DERIVATIVES ZENECA LTD (GB) 1999-01-20 EP claimed
EP-0773930-A1 AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS ZENECA LIMITED (GB) 1997-05-21 EP claimed
US-5321110-A Thickeners for shampoo, hair conditioners ISP INVESTMENTS INC. (US) 1994-06-14 US claimed
WO-1993025595-A1 CATIONIC POLYMER COMPOSITIONS ISP INVESTMENTS INC. (US) 1993-12-23 WO claimed
EP-0238883-B1 OXABICYCLOHEPTANE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND USE SUNTORY LIMITED (JP) 1990-05-09 EP claimed
EP-0065823-A1 Heterocyclic guanidines as histamine H-2 antagonists IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-12-01 EP claimed
US-3997534-A PARASITICIDES, NEMATOCIDES HOECHST AKTIENGESELLSCHAFT (DT) 1976-12-14 US claimed