⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557090 | 1.00 | — | — | |
| SCHEMBL248268 | 0.93 | — | — | |
| SCHEMBL4556830 | 0.93 | — | — | |
| SCHEMBL4556501 | 0.90 | — | — | |
| SCHEMBL4556846 | 0.90 | — | — | |
| SCHEMBL168922 | 0.90 | — | — | |
| SCHEMBL2081256 | 0.90 | — | — | |
| SCHEMBL414445 | 0.86 | — | — | |
| SCHEMBL4557221 | 0.77 | CXCR4 (0.33) | — | |
| SCHEMBL5508323 | 0.75 | KMT2A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9603829-B2 | HSP90 inhibitors with modified toxicity | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2017-03-28 | — | — | US | claimed |
| EP-2190291-B1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | UNIV COLORADO REGENTS (US) | 2015-10-14 | — | — | EP | claimed |
| US-20140315845-A1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE | 2014-10-23 | — | — | US | claimed |
| US-8551964-B2 | Hsp90 inhibitors with modified toxicity | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2013-10-08 | — | — | US | claimed |
| WO-2013074695-A1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2013-05-23 | — | — | WO | claimed |
| US-20120022011-A1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2012-01-26 | — | — | US | claimed |
| US-7902182-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-03-08 | — | — | US | claimed |
| EP-2190291-A1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | The Regents of the University of Colorado (US) | 2010-06-02 | — | — | EP | claimed |
| US-7608611-B2 | Hsp90 inhibitors, methods of making and uses therefor | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2009-10-27 | — | — | US | claimed |
| EP-1863769-A4 | HSP90 INHIBITORS, METHODS OF MAKING AND USES THEREFOR | UNIV COLORADO (US) | 2009-03-18 | — | — | EP | claimed |
| EP-1305024-A1 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS IC | Alteon, Inc. (US) | 2003-05-02 | — | — | EP | claimed |
| US-20020183365-A1 | Method for treating fibrotic diseases or other indications IIIC | ALTEON, INC. | 2002-12-05 | — | — | US | claimed |
| US-20020177586-A1 | Method for treating fibrotic diseases or other indications ID | SYNVISTA THERAPEUTICS, INC. | 2002-11-28 | — | — | US | claimed |
| US-20020160993-A1 | Method for treating glaucoma IC | SYNVISTA THERAPEUTICS, INC. | 2002-10-31 | — | — | US | claimed |
| US-20020156080-A1 | Method for treating glaucoma IIIB | ALTEON, INC. | 2002-10-24 | — | — | US | claimed |
| WO-2002067851-A2 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS IIIC | ALTEON, INC. (US) | 2002-09-06 | — | — | WO | claimed |
| WO-2002053158-A1 | METHOD FOR TREATING GLAUCOMA IB | ALTEON, INC. (US) | 2002-07-11 | — | — | WO | claimed |
| WO-2002053162-A1 | METHOD FOR TREATING GLAUCOMA IIIB | ALTEON, INC. (US) | 2002-07-11 | — | — | WO | claimed |
| US-20020068729-A1 | Method for treating fibrotic diseases or other indications IC | ALTEON, INC. | 2002-06-06 | — | — | US | claimed |
| WO-2002007725-A1 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS IC | ALTEON, INC. (US) | 2002-01-31 | — | — | WO | claimed |