Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | HTT | P42858 | 3/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.71 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.71 |
| ▸ | RELA | Q04206 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | HTR3A | P46098 | 1/20 | 0.66 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29832726 | 1.00 | NPC1 (0.71) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL31184229 | 1.00 | NPC1 (0.71) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL31326700 | 0.89 | MAPT (0.57) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7689945 | 0.85 | MAPT (0.53) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL31184151 | 0.84 | NPC1 (0.72) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29832295 | 0.84 | NPC1 (0.72) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1443423 | 0.82 | HTT (0.57) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1442062 | 0.82 | HTT (0.57) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3552442 | 0.82 | NPC1 (0.70) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1713999 | 0.82 | NPC1 (0.70) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023083247-A1 | INTERMEDIATE COMPOUND OF QUINOXALINE AND PREPARATION PROCESS THEREOF | 4B TECHNOLOGIES (SUZHOU) LIMITED (CN) | 2023-05-19 | — | — | WO | disclosed |
| WO-2023082145-A1 | INTERMEDIATE COMPOUND OF QUINOXALINE AND PREPARATION PROCESS THEREOF | 4B TECHNOLOGIES (SUZHOU) LIMITED (CN) | 2023-05-19 | — | — | WO | disclosed |
| US-20230049719-A1 | PYRAZOLO[3,4-B]PYRAZINE SHP2 PHOSPHATASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-02-16 | — | — | US | disclosed |
| EP-4111863-A1 | PHOSPHORUS USE EFFICIENCY ENHANCERS AS PLANT GROWTH PROMOTORS | EuroChem Antwerpen (BE) | 2023-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230049719-A1 | PYRAZOLO[3,4-B]PYRAZINE SHP2 PHOSPHATASE INHIBITORS | PTPN5, PTPRZ1, PTPN1 | NPC1 3811/4885RAB9A 2158/4885MAPT 382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.