Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.57 |
| ▸ | INSR | P06213 | 6/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521480 | 0.87 | JAK2 (0.66) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL16530415 | 0.84 | ALK (0.68) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL520762 | 0.81 | ALK (0.74) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL16530354 | 0.80 | ALK (0.65) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL519185 | 0.79 | JAK2 (0.71) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL521512 | 0.78 | ALK (0.72) | JAK2ALKINSRCYP3A4 | |
| SCHEMBL16530367 | 0.78 | ALK (0.68) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL521617 | 0.78 | JAK2 (0.64) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL519908 | 0.77 | JAK2 (0.80) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL16530399 | 0.77 | INSR (0.66) | JAK2ALKINSRCYP3A4PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |