Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.37 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.35 |
| ▸ | FAAH | O00519 | 5/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | YES1 | P07947 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | FGR | P09769 | 1/20 | 0.33 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.33 |
| ▸ | GRK4 | P32298 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24832871 | 0.89 | BTK (0.46) | BTKJAK3LCKPIK3CDFAAH | |
| SCHEMBL24832844 | 0.76 | JAK3 (0.41) | BTKJAK3LCKPIK3CDPIK3R1 | |
| SCHEMBL30165882 | 0.75 | LCK (0.40) | BTKJAK3LCKMAP4K4IRAK4 | |
| SCHEMBL24833598 | 0.71 | JAK3 (0.38) | BTKJAK3LCKPIK3CDPIK3R1 | |
| SCHEMBL24833200 | 0.68 | BTK (0.50) | BTKJAK3FAAH | |
| SCHEMBL24832840 | 0.66 | JAK3 (0.53) | BTKJAK3LCK | |
| SCHEMBL16764386 | 0.66 | JAK3 (0.53) | BTKJAK3LCK | |
| SCHEMBL16764385 | 0.66 | JAK3 (0.53) | BTKJAK3LCK | |
| SCHEMBL24834050 | 0.66 | JAK3 (0.53) | BTKJAK3LCKPIK3CDPIK3R1 | |
| SCHEMBL16764192 | 0.66 | JAK3 (0.53) | BTKJAK3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023274390-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2023-01-05 | — | — | WO | disclosed |