Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 10/20 | 0.40 |
| ▸ | JAK3 | P52333 | 10/20 | 0.40 |
| ▸ | BTK | Q06187 | 7/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31039919 | 0.79 | JAK3 (0.41) | LCKJAK3BTKHRH3EGFR | |
| SCHEMBL30165812 | 0.76 | FAAH (0.47) | LCKJAK3BTKHRH3 | |
| SCHEMBL30161265 | 0.75 | JAK3 (0.46) | LCKJAK3BTKHRH3EGFR | |
| SCHEMBL30160837 | 0.75 | JAK3 (0.51) | LCKJAK3BTKEGFR | |
| SCHEMBL24832869 | 0.75 | BTK (0.37) | LCKJAK3BTKMAP4K4IRAK4 | |
| SCHEMBL24832871 | 0.75 | BTK (0.46) | LCKJAK3BTKIRAK4 | |
| SCHEMBL24834062 | 0.74 | JAK3 (0.61) | LCKJAK3BTKEGFR | |
| SCHEMBL30161234 | 0.73 | LCK (0.45) | LCKJAK3BTKHRH3EGFR | |
| SCHEMBL31039905 | 0.73 | JAK3 (0.42) | LCKJAK3BTKHRH3EGFR | |
| SCHEMBL29931205 | 0.72 | JAK3 (0.59) | LCKJAK3BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557933-B | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-115557933-A | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-01-03 | — | — | CN | disclosed |