Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25074184 | 0.82 | CRBN (0.57) | CRBNDDB1POLB | |
| SCHEMBL25501664 | 0.82 | CRBN (0.57) | CRBNDDB1POLB | |
| SCHEMBL29990479 | 0.82 | CRBN (0.60) | CRBNDDB1POLB | |
| SCHEMBL30778437 | 0.82 | CRBN (0.69) | CRBNDDB1POLB | |
| SCHEMBL30066434 | 0.82 | CRBN (0.60) | CRBNDDB1POLB | |
| SCHEMBL25074524 | 0.82 | CRBN (0.60) | CRBNDDB1POLB | |
| SCHEMBL25074141 | 0.82 | CRBN (0.60) | CRBNDDB1POLB | |
| SCHEMBL24670590 | 0.82 | CRBN (0.60) | CRBNDDB1POLB | |
| SCHEMBL25501627 | 0.82 | CRBN (0.69) | CRBNDDB1POLB | |
| SCHEMBL25500434 | 0.82 | CRBN (0.60) | CRBNDDB1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112692-A1 | CASITAS B-LINEAGE LYMPHOMA PROTOONCOGENE B (CBL-B) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |
| WO-2023116934-A1 | KRASG12D PROTEIN HYDROLYSIS REGULATOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 苏州泽璟生物制药股份有限公司 | 2023-06-29 | — | — | WO | disclosed |
| WO-2023023255-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-02-23 | — | — | WO | disclosed |
| WO-2023274390-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2023-01-05 | — | — | WO | disclosed |