Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.73 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.50 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24833727 | 0.85 | CRBN (0.71) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL24319680 | 0.85 | CRBN (0.78) | CRBNDDB1IKZF3HDAC6 | |
| SCHEMBL23594040 | 0.84 | CRBN (0.70) | CRBNDDB1IKZF3 | |
| SCHEMBL19586301 | 0.84 | CRBN (1.00) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL23594041 | 0.84 | CRBN (0.70) | CRBNDDB1IKZF3 | |
| SCHEMBL23594038 | 0.84 | CRBN (0.70) | CRBNDDB1IKZF3 | |
| SCHEMBL23594202 | 0.83 | CRBN (0.73) | CRBNDDB1IKZF3HDAC6 | |
| SCHEMBL26264014 | 0.82 | CRBN (0.61) | CRBNDDB1IKZF3 | |
| SCHEMBL5740213 | 0.82 | CRBN (0.71) | CRBNDDB1IKZF3 | |
| SCHEMBL30301972 | 0.82 | CRBN (0.71) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023274390-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2023-01-05 | — | — | WO | disclosed |