Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.78 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27267043 | 0.92 | CRBN (0.69) | CRBNDDB1IKZF3 | |
| SCHEMBL26972238 | 0.89 | CRBN (0.62) | CRBNHDAC6 | |
| SCHEMBL19586301 | 0.87 | CRBN (1.00) | CRBNDDB1IKZF3 | |
| SCHEMBL30301972 | 0.87 | CRBN (0.71) | CRBNDDB1IKZF3 | |
| SCHEMBL5740213 | 0.87 | CRBN (0.71) | CRBNDDB1IKZF3 | |
| SCHEMBL30159778 | 0.87 | CRBN (0.71) | CRBNDDB1IKZF3 | |
| SCHEMBL23594202 | 0.85 | CRBN (0.73) | CRBNDDB1IKZF3HDAC6 | |
| SCHEMBL24833730 | 0.85 | CRBN (0.73) | CRBNDDB1IKZF3HDAC6 | |
| SCHEMBL26475116 | 0.84 | CRBN (0.74) | CRBNDDB1IKZF3 | |
| SCHEMBL19586568 | 0.84 | CRBN (0.70) | CRBNDDB1IKZF3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072270-A1 | PROTAC COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF | 百极弘烨(南通)医药科技有限公司 | 2023-05-04 | — | — | WO | disclosed |
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |