Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | ARAF | P10398 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KIF5B | P33176 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24399558 | 0.89 | RAF1 (0.54) | EGFRBRAFRAF1CSF1RARAF | |
| SCHEMBL30162852 | 0.89 | RAF1 (0.54) | EGFRBRAFRAF1CSF1RARAF | |
| SCHEMBL24835283 | 0.87 | EGFR (0.39) | EGFRBRAFRAF1CSF1RARAF | |
| SCHEMBL25371810 | 0.86 | EGFR (0.46) | EGFRBRAFRAF1CSF1RARAF | |
| SCHEMBL30400384 | 0.86 | EGFR (0.46) | EGFRBRAFRAF1CSF1RARAF | |
| SCHEMBL26207960 | 0.85 | LRRK2 (0.48) | EGFRBRAFRAF1CSF1RARAF | |
| SCHEMBL24399760 | 0.83 | BRAF (0.45) | EGFRBRAFRAF1CSF1RARAF | |
| SCHEMBL24834723 | 0.81 | EGFR (0.41) | EGFRBRAFRAF1CSF1RARAF | |
| SCHEMBL29638582 | 0.81 | BRAF (0.35) | EGFRBRAFRAF1CSF1RARAF | |
| SCHEMBL26210990 | 0.81 | BRAF (0.35) | EGFRBRAFRAF1CSF1RARAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278981-A1 | SYNTHESIS OF A BIS-MESYLATE SALT OF 4-AMINO-N-(1 -((3-CHLORO-2- FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2- D]PYRIMIDINE-7-CARBOXAMIDE AND INTERMEDIATES THERETO | GENENTECH, INC. (US) | 2023-01-05 | — | — | WO | disclosed |