Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.54 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | ARAF | P10398 | 1/20 | 0.54 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.54 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 13/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24399558 | 1.00 | RAF1 (0.54) | RAF1BRAFCSF1RARAFDDR1 | |
| SCHEMBL24399760 | 0.90 | BRAF (0.45) | RAF1BRAFCSF1RARAFDDR1 | |
| SCHEMBL24834657 | 0.89 | EGFR (0.45) | RAF1BRAFCSF1RARAFDDR1 | |
| SCHEMBL30400384 | 0.82 | EGFR (0.46) | RAF1BRAFCSF1RARAFDDR1 | |
| SCHEMBL25371810 | 0.82 | EGFR (0.46) | RAF1BRAFCSF1RARAFDDR1 | |
| SCHEMBL26207960 | 0.82 | LRRK2 (0.48) | RAF1BRAFCSF1RARAFDDR1 | |
| SCHEMBL24399774 | 0.82 | RAF1 (0.51) | RAF1BRAFCSF1RARAFDDR1 | |
| SCHEMBL30401683 | 0.81 | RAF1 (0.49) | RAF1BRAFCSF1RARAFDDR1 | |
| SCHEMBL24927453 | 0.81 | RAF1 (0.49) | RAF1BRAFCSF1RARAFDDR1 | |
| Hydrochloric Acid SCHEMBL31369340 | 0.80 | RAF1 (0.48) | RAF1BRAFCSF1RARAFDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4363424-A1 | SYNTHESIS OF A BIS-MESYLATE SALT OF 4-AMINO-N-(1 -((3-CHLORO-2- FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2- D]PYRIMIDINE-7-CARBOXAMIDE AND INTERMEDIATES THERETO | Genentech, Inc. (US) | 2024-05-08 | — | — | EP | disclosed |
| CN-117580840-A | Synthesis of bis-mesylate salt of 4-amino-N- (1- ((3-chloro-2-fluorophenyl) amino) -6-methylisoquinolin-5-yl) thieno [3,2-D ] pyrimidine-7-carboxamide and intermediates thereof | 基因泰克公司 | 2024-02-20 | — | — | CN | disclosed |
| WO-2023278981-A1 | SYNTHESIS OF A BIS-MESYLATE SALT OF 4-AMINO-N-(1 -((3-CHLORO-2- FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2- D]PYRIMIDINE-7-CARBOXAMIDE AND INTERMEDIATES THERETO | GENENTECH, INC. (US) | 2023-01-05 | — | — | WO | disclosed |