Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | MAT2A | P31153 | 4/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 2/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24835094 | 0.86 | PARP1 (0.34) | ALDH1A1GAAPDE4BPDE3ADAO | |
| SCHEMBL4200098 | 0.75 | PARP1 (0.38) | PDE4BPDE3ADAOMAT2APARP1 | |
| SCHEMBL26732614 | 0.73 | PDE4B (0.36) | PDE4BPDE3AMAT2APARP1HPGD | |
| SCHEMBL24834510 | 0.72 | PDE4B (0.40) | PDE4BPDE3AMAT2APARP1PKM | |
| SCHEMBL30169851 | 0.72 | PDE4B (0.38) | GAAPDE4BPDE3AMAT2APARP1 | |
| SCHEMBL24834870 | 0.72 | PDE4B (0.38) | GAAPDE4BPDE3AMAT2APARP1 | |
| SCHEMBL30169859 | 0.72 | PDE4B (0.40) | PDE4BPDE3AMAT2APARP1PKM | |
| SCHEMBL30771968 | 0.71 | CCR1 (0.44) | GAAPARP1 | |
| SCHEMBL24855723 | 0.71 | CCR1 (0.44) | GAAPARP1 | |
| SCHEMBL2331355 | 0.68 | TRPV4 (0.41) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4363418-A1 | 5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES | JANSSEN Pharmaceutica NV (BE) | 2024-05-08 | — | — | EP | disclosed |
| CN-117545757-A | 5-oxo-pyrido [2,3-d ] pyridazin-6 (5H) -ylacetamides | 詹森药业有限公司 | 2024-02-09 | — | — | CN | disclosed |
| WO-2023275230-A1 | 5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2023-01-05 | — | — | WO | disclosed |
| WO-2023275230-A1 | 5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2023-01-05 | — | — | WO | disclosed |