Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | RGS12 | O14924 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16174384 | 1.00 | KDM4E (0.62) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL8230082 | 1.00 | KDM4E (0.62) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL791742 | 1.00 | KDM4E (0.62) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL12581063 | 1.00 | KDM4E (0.62) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL12435784 | 1.00 | KDM4E (0.62) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL16172571 | 1.00 | KDM4E (0.62) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL23626333 | 0.81 | LMNA (0.52) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL8889599 | 0.81 | LMNA (0.52) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL517001 | 0.81 | KDM4E (0.65) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL6689612 | 0.81 | KDM4E (0.65) | KDM4ELMNAADRA2CADRA2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022254601-A1 | NANOPARTICLE-CONTAINING FILM, LIGHT-EMITTING ELEMENT, PRODUCTION METHOD FOR NANOPARTICLE-CONTAINING FILM | シャープ株式会社 | 2022-12-08 | — | — | WO | disclosed |
| US-10851082-B2 | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2) | NORTHWESTERN UNIVERSITY (US) | 2020-12-01 | — | — | US | disclosed |
| EP-3564235-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | Northwestern University (US) | 2019-11-06 | — | — | EP | disclosed |
| US-20170121326-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | NORTHWESTERN UNIVERSITY (US) | 2017-05-04 | — | — | US | disclosed |
| WO-2017075367-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | NORTHWESTERN UNIVERSITY (US) | 2017-05-04 | — | — | WO | disclosed |
| CN-103467730-B | Carbamate compounds | Asahi Kasei Chemical K. K. (JP) | 2015-12-23 | — | — | CN | disclosed |
| CN-101868445-B | Method for producing isocyanate and aromatic hydroxy compound | ASAHI CHEMICAL CORP | 2014-06-18 | — | — | CN | disclosed |
| US-8717565-B2 | Optically active functional fluid markers | THE LUBRIZOL CORPORATION (US) | 2014-05-06 | — | — | US | disclosed |
| CN-103467730-A | Carbamate compound | ASAHI KASEI CHEMICAL CORP | 2013-12-25 | — | — | CN | disclosed |
| EP-2376894-A1 | OPTICALLY ACTIVE FUNCTIONAL FLUID MARKERS | The Lubrizol Corporation (US) | 2011-10-19 | — | — | EP | disclosed |
| CN-101868445-A | Method for producing isocyanate and aromatic hydroxy compound | ASAHI CHEMICAL CORP (JP) | 2010-10-20 | — | — | CN | disclosed |
| WO-2010077753-A1 | OPTICALLY ACTIVE FUNCTIONAL FLUID MARKERS | THE LUBRIZOL CORPORATION (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077754-A1 | OPTICALLY ACTIVE FUNCTIONAL FLUID MARKERS | THE LUBRIZOL CORPORATION (US) | 2010-07-08 | — | — | WO | disclosed |
| CN-100577738-C | Flame retardant resin composition | POLYPLASTICS CO | 2010-01-06 | — | — | CN | disclosed |
| EP-1606267-B1 | PYRAZINE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | PFIZER PROD INC (US) | 2008-07-30 | — | — | EP | disclosed |
| US-7199123-B2 | Pyrazine compounds as transforming growth factor (TGF) compounds | PFIZER INC. (US) | 2007-04-03 | — | — | US | disclosed |
| CN-1596288-A | Flame-retardant resin composition | POLYPLASTICS CO (JP) | 2005-03-16 | — | — | CN | disclosed |
| CN-1046507-C | Heterocyclic compounds for the treatment of central nervous system and cardiovascular diseases | UPJOHN CO (US) | 1999-11-17 | — | — | CN | disclosed |
| CN-1139431-A | Heterocyclic compounds for the treatment of central nervous system and cardiovascular diseases | PHARMACIA & UPJOHN CO LLC (US) | 1997-01-01 | — | — | CN | disclosed |
| US-4628120-A | REARRANGEMENTS USING ORGANOALUMINUM COMPOUNDS | TOYO STAUFFER CHEMICAL CO., LTD. (JP) | 1986-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10851082-B2 | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2) | MAP4K2, MAP3K20, MKNK2 | KDM4E 2527/4885LMNA 2877/4885ADRA2C 3741/4885 |
| US-20170121326-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | MAP4K2, MAP3K20, MKNK2 | KDM4E 2527/4885LMNA 2877/4885ADRA2C 3741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.