Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL8826193 | 0.81 | CHEK1 (0.38) | CHEK1 | |
| SCHEMBL30942632 | 0.80 | CHEK1 (0.42) | CHEK1FGFR1 | |
| SCHEMBL9081 | 0.80 | CHEK1 (0.42) | CHEK1FGFR1 | |
| SCHEMBL8716026 | 0.79 | CHEK1 (0.41) | CHEK1FGFR1 | |
| SCHEMBL9798919 | 0.79 | CHEK1 (0.41) | CHEK1FGFR1 | |
| Hydrochloric Acid SCHEMBL11162213 | 0.79 | CHEK1 (0.41) | CHEK1FGFR1 | |
| SCHEMBL248371 | 0.77 | HTT (0.46) | CHEK1 | |
| SCHEMBL11167998 | 0.76 | CHEK1 (0.35) | CHEK1FGFR1 | |
| Acetone SCHEMBL3279080 | 0.74 | CHEK1 (0.36) | CHEK1FGFR1FGFR4 | |
| SCHEMBL253743 | 0.71 | KDM4A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588469-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| US-20130096134-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-18 | — | — | US | disclosed |
| WO-2012003271-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096134-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, SSB, MALT1 | CHEK1 1319/4885FGFR1 3186/4885FGFR4 3142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.