Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.38 |
| ▸ | CDK1 | P06493 | 5/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11596392 | 0.83 | ADORA2A (0.49) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL2475932 | 0.82 | ADORA2A (0.64) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL31331738 | 0.82 | ADORA2A (0.64) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL21539218 | 0.79 | ADORA2A (0.51) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL11258096 | 0.79 | ADORA2A (0.47) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL11595833 | 0.76 | ADORA2A (0.45) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL11596964 | 0.76 | ADORA2A (0.45) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL11596855 | 0.76 | ADORA2A (0.51) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL11596724 | 0.75 | ADORA2A (0.50) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL21127815 | 0.75 | ADORA2A (0.46) | ADORA2AADORA2BADORA1PI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588469-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| US-20130096134-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-18 | — | — | US | disclosed |
| WO-2012003271-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096134-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, SSB, MALT1 | ADORA2A 1672/4885ADORA2B 2729/4885ADORA1 4082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.