Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | GOT1 | P17174 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 6/20 | 0.43 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2486666 | 0.89 | NPC1 (0.47) | PDGFRBTRPV1NPC1RAB9AMAPT | |
| SCHEMBL2483986 | 0.87 | NPC1 (0.40) | BRS3PDGFRBTRPV1NPC1RAB9A | |
| SCHEMBL2806247 | 0.84 | PDGFRB (0.52) | BRS3PDGFRBGOT1NPC1RAB9A | |
| SCHEMBL2805744 | 0.80 | PDGFRB (0.48) | BRS3PDGFRBGOT1NPC1RAB9A | |
| SCHEMBL2490058 | 0.78 | MAPT (0.44) | TRPV1NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL2804674 | 0.77 | BRS3 (0.50) | BRS3PDGFRBGOT1TRPV1NPC1 | |
| SCHEMBL2802809 | 0.75 | PDGFRB (0.62) | PDGFRBTRPV1NPC1RAB9AFAAH | |
| SCHEMBL2802299 | 0.74 | NPC1 (0.61) | NPC1RAB9AALDH1A1MAPTMAPK1 | |
| SCHEMBL2488481 | 0.74 | ROCK2 (0.36) | TRPV1ALDH1A1 | |
| SCHEMBL1000524 | 0.73 | TRPV1 (0.73) | TRPV1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379551-A1 | SUBSTITUTED PYRAZOLO [3, 4-B]PYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078427-A1 | SUBSTITUTED PYRAZOLO [3, 4-B] PYRIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |