SCHEMBL24840463

SCHEMBL24840463

Cc1ccc(-c2nnc(NC3CCCN(C)C3)c3c2CCC3)c(O)c1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 11/20 0.69
IL1B P01584 12/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30108762 1.00 NLRP3 (0.69) NLRP3IL1B
SCHEMBL24575127 1.00 NLRP3 (0.69) NLRP3IL1B
SCHEMBL24575132 0.98 NLRP3 (0.69) NLRP3IL1B
SCHEMBL30108747 0.98 NLRP3 (0.69) NLRP3IL1B
SCHEMBL24840268 0.98 NLRP3 (0.69) NLRP3IL1B
SCHEMBL28934491 0.97 NLRP3 (0.68) NLRP3IL1B
SCHEMBL30108759 0.97 NLRP3 (0.68) NLRP3IL1B
SCHEMBL28934481 0.97 NLRP3 (0.68) NLRP3IL1B
SCHEMBL30108788 0.97 NLRP3 (0.68) NLRP3IL1B
SCHEMBL24575128 0.91 NLRP3 (0.76) NLRP3IL1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117881401-A NLRP3 modulators 祖玛珍生物科学有限公司 2024-04-12 CN disclosed
WO-2023278438-A1 NLRP3 MODULATORS ZOMAGEN BIOSCIENCES LTD (US) 2023-01-05 WO disclosed
CN-115433163-A NLRP3 inflammasome inhibitor and application thereof 药捷安康(南京)科技股份有限公司 2022-12-06 CN disclosed