Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895795 | 0.91 | AGER (0.41) | AGERNPC1LMNAMAPK1RAB9A | |
| SCHEMBL6895313 | 0.80 | AGER (0.51) | AGERNPC1LMNAMAPK1RAB9A | |
| SCHEMBL1283498 | 0.80 | AGER (0.55) | AGERNPC1LMNAMAPK1RAB9A | |
| SCHEMBL1283344 | 0.80 | AGER (0.55) | AGERNPC1LMNAMAPK1RAB9A | |
| SCHEMBL1283677 | 0.80 | AGER (0.57) | AGERNPC1LMNAMAPK1RAB9A | |
| SCHEMBL1283836 | 0.79 | AGER (0.78) | AGERCXCR1 | |
| SCHEMBL1283673 | 0.78 | AGER (0.57) | AGERNPC1LMNAMAPK1RAB9A | |
| SCHEMBL1283582 | 0.78 | AGER (0.72) | AGERNR1H2 | |
| SCHEMBL13314509 | 0.77 | AGER (0.52) | AGERATM | |
| SCHEMBL1282765 | 0.77 | AGER (0.60) | AGERNPC1LMNAMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482931-B1 | MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE | TRANSTECH PHARMA INC (US) | 2011-10-19 | — | — | EP | disclosed |