Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 18/20 | 0.72 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2486050 | 0.90 | PTGDR2 (0.74) | PTGDR2HCRTR1HCRTR2 | |
| SCHEMBL2483121 | 0.84 | PTGDR2 (0.65) | PTGDR2 | |
| SCHEMBL2482558 | 0.84 | PTGDR2 (1.00) | PTGDR2 | |
| SCHEMBL11959127 | 0.83 | PTGDR2 (0.82) | PTGDR2 | |
| SCHEMBL2486047 | 0.82 | PTGDR2 (0.95) | PTGDR2 | |
| SCHEMBL2486611 | 0.80 | PTGDR2 (0.59) | PTGDR2 | |
| SCHEMBL2481296 | 0.79 | PTGDR2 (0.66) | PTGDR2 | |
| SCHEMBL2484605 | 0.73 | PTGDR2 (0.72) | PTGDR2HCRTR1HCRTR2 | |
| SCHEMBL2483157 | 0.70 | PTGDR2 (1.00) | PTGDR2 | |
| SCHEMBL2483198 | 0.68 | PTGDR2 (0.38) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891075-B1 | TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS | MERCK SERONO SA (CH) | 2011-10-19 | — | — | EP | disclosed |