SCHEMBL2483121

SCHEMBL2483121

CC(C)(C)C(C(=O)O)N1C(=O)C2(CC(=O)N(Cc3ccccc3)C2)c2cc(Cl)ccc21

nearest known ligand 0.65

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 19/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2486611 0.90 PTGDR2 (0.59) PTGDR2
SCHEMBL2481296 0.88 PTGDR2 (0.66) PTGDR2
SCHEMBL2484253 0.84 PTGDR2 (0.72) PTGDR2
SCHEMBL2480425 0.79 PTGDR2 (1.00) PTGDR2
SCHEMBL11959129 0.78 PTGDR2 (0.76) PTGDR2
SCHEMBL2486050 0.77 PTGDR2 (0.74) PTGDR2
SCHEMBL2483198 0.77 PTGDR2 (0.38) PTGDR2
SCHEMBL958583 0.69 PTGDR2 (0.38) PTGDR2
SCHEMBL2484433 0.69 PTGDR2 (0.40) PTGDR2
SCHEMBL2485299 0.69 PTGDR2 (0.88) PTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1891075-B1 TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS MERCK SERONO SA (CH) 2011-10-19 EP disclosed