Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6408772 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2CHRM5CHRM3MEN1KMT2A | |
| SCHEMBL1969997 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2CHRM5CHRM3MEN1KMT2A | |
| SCHEMBL1970023 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2CHRM5CHRM3MEN1KMT2A | |
| SCHEMBL28259536 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13667433 | 0.75 | — | — | |
| SCHEMBL5617 | 0.75 | — | — | |
| SCHEMBL1889483 | 0.75 | — | — | |
| SCHEMBL8373239 | 0.75 | SMN1; SMN2 (0.38) | SMN1; SMN2CHRM5CHRM3MEN1KMT2A | |
| SCHEMBL293089 | 0.75 | — | — | |
| SCHEMBL27361473 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013130422-A1 | COMPOSITIONS AND METHODS FOR TREATING MITOCHONDRIAL DISEASES | BIOVISTA, INC. (US) | 2013-09-06 | — | — | WO | disclosed |
| EP-2375900-A1 | METHODS FOR TREATING MULTIPLE SCLEROSIS USING TETRACYCLIC PYRAZINOINDOLES | Biovista, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010068867-A1 | METHODS FOR TREATING MULTIPLE SCLEROSIS USING TETRACYCLIC PYRAZINOINDOLES | BIOVISTA, INC. (US) | 2010-06-17 | — | — | WO | disclosed |