SCHEMBL24844633

SCHEMBL24844633

N/C(=N\O)c1cncc(F)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.52
CHRNB2 P17787 2/20 0.41
CHRNA4 P43681 2/20 0.41
CHRNB4 P30926 1/20 0.39
CHRNA3 P32297 1/20 0.39
KDM1A O60341 10/20 0.36
ALOX5 P09917 1/20 0.34
RECQL P46063 1/20 0.33
LMNA P02545 2/20 0.31
KMT2A Q03164 2/20 0.31
GFER P55789 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
PARP1 P09874 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
DDO Q99489 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31137891 0.79 SCN10A (0.47) CHRNB4CHRNA3ALOX5
SCHEMBL4392027 0.78 HCAR2 (0.53) HCAR2
SCHEMBL4392022 0.78 HCAR2 (0.53) HCAR2
SCHEMBL641873 0.76 CES2 (0.44) KDM1ARECQLLMNAKMT2AGFER
SCHEMBL641872 0.76 CES2 (0.44) KDM1ARECQLLMNAKMT2AGFER
SCHEMBL640929 0.76 HCAR2 (0.52) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL4217221 0.76 POLB (0.52) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL640930 0.76 HCAR2 (0.52) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL29478735 0.76 HCAR2 (0.52) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL14755489 0.76 HCAR2 (0.52) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023275744-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS TECNIMEDE - Sociedade Técnico-medicinal, SA (PT) 2023-01-05 WO disclosed