SCHEMBL24847757

SCHEMBL24847757

CC(C)c1ccc(-c2cc(-c3cc4c([nH]3)C3(CCC3)CNC4=O)ccn2)cc1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 19/20 0.54
CDC7 O00311 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24847832 0.98 MAPKAPK2 (0.54) MAPKAPK2CDC7
SCHEMBL26443735 0.96 MAPKAPK2 (0.56) MAPKAPK2CDC7
SCHEMBL26449268 0.89 MAPKAPK2 (0.50) MAPKAPK2CDC7
SCHEMBL24846729 0.88 MAPKAPK2 (0.51) MAPKAPK2CDC7
SCHEMBL26449295 0.87 MAPKAPK2 (0.52) MAPKAPK2CDC7
SCHEMBL24847381 0.86 MAPKAPK2 (0.53) MAPKAPK2CDC7
SCHEMBL24847430 0.86 MAPKAPK2 (0.69) MAPKAPK2
SCHEMBL24847509 0.86 MAPKAPK2 (0.53) MAPKAPK2CDC7
SCHEMBL29306726 0.85 MAPKAPK2 (0.53) MAPKAPK2CDC7
SCHEMBL26443765 0.84 MAPKAPK2 (0.50) MAPKAPK2CDC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024148060-A1 MK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2024-07-11 WO disclosed
US-20230135894-A1 MK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-05-04 US disclosed
US-20230135894-A1 MK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-05-04 US disclosed
WO-2023278759-A1 MK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-01-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230135894-A1 MK2 DEGRADERS AND USES THEREOF MKNK2, MKRN3, DUS2 MAPKAPK2 70/4885CDC7 864/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.