Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2486917 | 0.97 | MAPT (0.39) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL418447 | 0.96 | BIRC2 (0.41) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL413397 | 0.94 | RAB9A (0.46) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL417755 | 0.86 | BIRC2 (0.44) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL418454 | 0.86 | MAPT (0.48) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL417533 | 0.81 | MAPT (0.50) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL413454 | 0.81 | MAPT (0.50) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL2486807 | 0.81 | HTR2C (0.31) | MAPTSMN1; SMN2TSHRHSD17B10KMT2A | |
| SCHEMBL2486415 | 0.81 | MAPT (0.39) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL412375 | 0.80 | MAPT (0.52) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376431-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | LABORATOIRE BIODIM (FR) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010066847-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | CELLVIR (FR) | 2010-06-17 | — | — | WO | disclosed |