SCHEMBL24848165

SCHEMBL24848165

CC(C)(C)OC(=O)c1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 12/20 0.55
DDB1 Q16531 4/20 0.55
GSPT1 P15170 2/20 0.55
CYP2C19 P33261 1/20 0.55
KCNH2 Q12809 1/20 0.55
IKZF3 Q9UKT9 1/20 0.54
CSNK1A1 P48729 3/20 0.46
IKZF2 Q9UKS7 5/20 0.43
WIZ O95785 1/20 0.43
IKZF1 Q13422 1/20 0.42
SALL4 Q9UJQ4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24848617 0.89 CRBN (0.58) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847420 0.89 CRBN (0.60) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24848011 0.88 CRBN (0.58) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847688 0.88 CRBN (0.52) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL28881284 0.87 CRBN (0.69) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847687 0.87 CRBN (0.58) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847729 0.87 CRBN (0.62) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847357 0.86 CRBN (0.61) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847775 0.86 CRBN (0.61) CRBNDDB1GSPT1CYP2C19KCNH2
SCHEMBL24847358 0.86 CRBN (0.60) CRBNDDB1GSPT1CYP2C19KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023274246-A1 AMIDE COMPOUND AND USE THEREOF 成都分迪药业有限公司 2023-01-05 WO disclosed