Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.69 |
| ▸ | GSPT1 | P15170 | 4/20 | 0.69 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.69 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 6/20 | 0.54 |
| ▸ | IKZF2 | Q9UKS7 | 10/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28881359 | 0.91 | CRBN (0.69) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL23883030 | 0.89 | CRBN (0.75) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL1413440 | 0.89 | CRBN (0.77) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL1403552 | 0.88 | CRBN (0.74) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL28881292 | 0.88 | CRBN (0.73) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL24848165 | 0.87 | CRBN (0.55) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL1413606 | 0.87 | CRBN (0.80) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL60892 | 0.87 | CRBN (0.77) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL30244593 | 0.87 | CRBN (0.58) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL30244595 | 0.87 | CRBN (0.58) | CRBNGSPT1DDB1IKZF3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304606-B | Degradation agent for simultaneously targeting BTK and GSPT proteins | 清华大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-115304606-A | Degradation agent for simultaneously targeting BTK and GSPT1 proteins | 清华大学 | 2022-11-08 | — | — | CN | disclosed |