Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 10/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.46 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2484827 | 1.00 | CHRNA7 (0.49) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL744341 | 1.00 | CHRNA7 (0.49) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL746332 | 0.92 | CHRNA7 (0.48) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL746978 | 0.91 | CHRNA7 (0.47) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL744535 | 0.88 | CHRNA7 (0.41) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL746345 | 0.87 | PRKCZ (0.43) | SLC6A2SLC6A3 | |
| SCHEMBL744687 | 0.86 | CHRNA7 (0.49) | CHRNA7KCNH2SLC6A2SLC6A3 | |
| SCHEMBL743968 | 0.86 | CHRNA7 (0.53) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL2481429 | 0.85 | CHRNA7 (0.52) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL748372 | 0.84 | KCNH2 (0.53) | CHRNA7KCNH2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018380-B1 | Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives | ABBOTT LAB (US) | 2011-10-19 | — | — | EP | claimed |