Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 8/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.56 |
| ▸ | IDO1 | P14902 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | MAP3K9 | P80192 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.45 |
| ▸ | STK3 | Q13188 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPRA | P18433 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872850 | 0.92 | MAP2K1 (0.56) | MAP2K1MAP2K2IDO1MEN1KMT2A | |
| SCHEMBL4853895 | 0.91 | MEN1 (0.62) | MAP2K1MAP2K2IDO1MEN1KMT2A | |
| SCHEMBL2387610 | 0.88 | MAP2K1 (0.53) | MAP2K1MAP2K2IDO1MEN1KMT2A | |
| SCHEMBL4861973 | 0.88 | MAP2K1 (0.59) | MAP2K1MAP2K2IDO1MEN1KMT2A | |
| SCHEMBL29425442 | 0.86 | MAP2K1 (0.51) | MAP2K1MAP2K2IDO1MEN1KMT2A | |
| SCHEMBL23693639 | 0.86 | MAP2K1 (0.51) | MAP2K1MAP2K2IDO1MEN1KMT2A | |
| SCHEMBL5872858 | 0.86 | MAP2K1 (0.51) | MAP2K1MAP2K2IDO1MEN1KMT2A | |
| SCHEMBL4851710 | 0.85 | MAP2K1 (0.78) | MAP2K1MAP2K2IDO1MEN1KMT2A | |
| SCHEMBL29425477 | 0.85 | MAP2K1 (0.78) | MAP2K1MAP2K2IDO1MEN1KMT2A | |
| SCHEMBL6035677 | 0.85 | MAP2K1 (0.55) | MAP2K1MAP2K2IDO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002333-A1 | ARYLAMIDE DERIVATIVE HAVING ANTITUMOR ACTIVITY | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002333-A1 | ARYLAMIDE DERIVATIVE HAVING ANTITUMOR ACTIVITY | BRAF, NRAS, KRAS | MAP2K1 162/4885MAP2K2 132/4885IDO1 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.