Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.45 |
| ▸ | JAK1 | P23458 | 7/20 | 0.42 |
| ▸ | JAK3 | P52333 | 5/20 | 0.42 |
| ▸ | TYK2 | P29597 | 4/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 3/20 | 0.31 |
| ▸ | RET | P07949 | 3/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | FYN | P06241 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | YES1 | P07947 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31423892 | 0.89 | JAK2 (0.43) | JAK2JAK1JAK3TYK2MAP3K5 | |
| SCHEMBL31318305 | 0.89 | JAK2 (0.44) | JAK2JAK1JAK3TYK2MAP3K5 | |
| SCHEMBL31318300 | 0.89 | JAK2 (0.44) | JAK2JAK1JAK3TYK2MAP3K5 | |
| SCHEMBL31318301 | 0.88 | JAK2 (0.44) | JAK2JAK1JAK3TYK2MAP3K5 | |
| SCHEMBL31423990 | 0.84 | JAK2 (0.42) | JAK2JAK1JAK3TYK2MAP3K5 | |
| SCHEMBL23209359 | 0.83 | JAK2 (0.48) | JAK2JAK1JAK3TYK2MAP3K5 | |
| SCHEMBL29885909 | 0.83 | JAK2 (0.44) | JAK2JAK1JAK3TYK2MAP3K5 | |
| SCHEMBL23209401 | 0.83 | JAK2 (0.44) | JAK2JAK1JAK3TYK2MAP3K5 | |
| SCHEMBL31423928 | 0.83 | JAK2 (0.48) | JAK2JAK1JAK3TYK2MAP3K5 | |
| SCHEMBL30043068 | 0.83 | JAK2 (0.48) | JAK2JAK1JAK3TYK2MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025054386-A1 | CDK2 INHIBITORS AND USES THEREOF | ODYSSEY THERAPEUTICS, INC. (US) | 2025-03-13 | — | — | WO | disclosed |
| US-20230192706-A1 | BICYCLIC AMINES AS CDK2 INHIBITORS | INCYTE CORPORATION | 2023-06-22 | — | — | US | disclosed |
| US-20230192706-A1 | BICYCLIC AMINES AS CDK2 INHIBITORS | INCYTE CORPORATION | 2023-06-22 | — | — | US | disclosed |
| US-20230002376-A1 | BICYCLIC PYRAZOLYL AMINES AS CDK2 INHIBITORS | INCYTE CORPORATION | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002376-A1 | BICYCLIC PYRAZOLYL AMINES AS CDK2 INHIBITORS | CDK2, CCNI, CDK1 | JAK2 181/4885JAK1 331/4885JAK3 434/4885 |
| US-20230192706-A1 | BICYCLIC AMINES AS CDK2 INHIBITORS | CDK2, CCNI, CDK1 | JAK2 232/4885JAK1 605/4885JAK3 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.