Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 13/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 13/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30295720 | 1.00 | KEAP1 (0.46) | KEAP1NFE2L2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL31363146 | 0.85 | KMT2A (0.41) | KEAP1NFE2L2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29811519 | 0.85 | SMN1; SMN2 (0.40) | KEAP1NFE2L2SMN1; SMN2LMNAADRA2A | |
| SCHEMBL23144640 | 0.85 | SMN1; SMN2 (0.40) | KEAP1NFE2L2SMN1; SMN2LMNAADRA2A | |
| SCHEMBL24035759 | 0.81 | GAA (0.41) | KEAP1NFE2L2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29184902 | 0.80 | KEAP1 (0.36) | KEAP1NFE2L2ALDH1A1TSHR | |
| SCHEMBL4841484 | 0.80 | KMT2A (0.43) | SMN1; SMN2LMNATSHR | |
| SCHEMBL24035257 | 0.80 | KEAP1 (0.41) | KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL31363153 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1LMNAADRA2ACYP2D6 | |
| SCHEMBL4842133 | 0.75 | SMN1; SMN2 (0.38) | KEAP1NFE2L2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807644-B2 | Methods and compounds for restoring mutant p53 function | PMV PHARMACEUTICALS, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-11807644-B2 | Methods and compounds for restoring mutant p53 function | PMV PHARMACEUTICALS, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| CN-116710430-A | Methods and compounds for restoring mutant p53 function | 皮姆维制药公司 | 2023-09-05 | — | — | CN | disclosed |
| US-20230002403-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002403-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | TP53, TP53BP1, HRAS | KEAP1 1356/4885NFE2L2 884/4885SMN1; SMN2 3494/4885 |
| US-11807644-B2 | Methods and compounds for restoring mutant p53 function | TP53, TP53BP1, HRAS | KEAP1 1356/4885NFE2L2 884/4885SMN1; SMN2 3494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.