Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19580174 | 0.94 | TRPM8 (0.46) | TRPM8CYP1A2CYP2D6ALDH1A1PDE2A | |
| SCHEMBL2487809 | 0.93 | TRPM8 (0.46) | TRPM8CYP1A2CYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL19580159 | 0.91 | TRPM8 (0.55) | TRPM8CYP1A2ALOX15ALDH1A1TRPV4 | |
| SCHEMBL2445245 | 0.87 | TRPM8 (0.51) | TRPM8CYP1A2CYP2D6ALOX15ALDH1A1 | |
| SCHEMBL2445464 | 0.87 | TRPM8 (0.49) | TRPM8CYP1A2ALOX15CYP3A4CYP2C19 | |
| SCHEMBL2446624 | 0.86 | TRPM8 (0.46) | TRPM8CYP1A2ALOX15CYP3A4CYP2C19 | |
| SCHEMBL12331742 | 0.86 | TRPM8 (0.47) | TRPM8CYP1A2CYP2D6ALOX15ALDH1A1 | |
| SCHEMBL2448023 | 0.86 | TRPM8 (0.47) | TRPM8CYP1A2ALOX15CYP3A4CYP2C19 | |
| SCHEMBL19580157 | 0.84 | TRPM8 (0.57) | TRPM8PDE2AACHETSHRACP1 | |
| SCHEMBL2452146 | 0.84 | NPY5R (0.43) | TRPM8CYP1A2CYP2D6ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542552-B1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-15 | — | — | EP | disclosed |
| EP-2542552-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011109587-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-09 | — | — | WO | disclosed |