SCHEMBL248541

SCHEMBL248541

O=C(O)C1CC1(CF)CF

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 4/20 0.35
GRM4 Q14833 6/20 0.34
CYP1A2 P05177 3/20 0.34
ALDH1A1 P00352 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
GRM8 O00222 2/20 0.34
GRM6 O15303 2/20 0.34
ALOX15 P16050 2/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
KDM4E B2RXH2 1/20 0.34
SLC6A4 P31645 1/20 0.33
APLNR P35414 1/20 0.32
GRM2 Q14416 2/20 0.30
GRM3 Q14832 2/20 0.30
LMNA P02545 1/20 0.30
GRM5 P41594 1/20 0.30
MTOR P42345 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22396496 1.00 CYP2C19 (0.35) CYP2C19GRM4CYP1A2ALDH1A1TDP1
SCHEMBL14783304 0.77 CYP2C19 (0.36) CYP2C19GRM4CYP1A2ALDH1A1TDP1
SCHEMBL7003944 0.75 CYP2C19 (0.35) CYP2C19GRM4CYP1A2ALDH1A1TDP1
SCHEMBL21410715 0.75 CYP2C19 (0.35) CYP2C19GRM4CYP1A2ALDH1A1TDP1
SCHEMBL20798258 0.75 APLNR (0.37) CYP2C19GRM4CYP1A2ALDH1A1TDP1
SCHEMBL11518296 0.75 APLNR (0.37) CYP2C19GRM4CYP1A2ALDH1A1TDP1
SCHEMBL21410922 0.75 CYP2C19 (0.35) CYP2C19GRM4CYP1A2ALDH1A1TDP1
SCHEMBL248944 0.75 CYP2C19 (0.35) CYP2C19GRM4CYP1A2ALDH1A1TDP1
SCHEMBL6268424 0.71 APLNR (0.34) CYP2C19GRM4CYP1A2ALDH1A1TDP1
SCHEMBL1173556 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3704090-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY Calico Life Sciences LLC (US) 2020-09-09 EP disclosed
EP-3325475-A1 OXADIAZOLE DERIVATIVES USEFUL AS HDAC INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2018-05-30 EP disclosed
WO-2017014321-A1 OXADIAZOLE DERIVATIVES USEFUL AS HDAC INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-01-26 WO disclosed
EP-3071036-A1 PESTICIDAL COMPOSITIONS AND RELATED METHODS Dow AgroSciences LLC (US) 2016-09-28 EP disclosed
WO-2015061165-A1 PESTICIDAL COMPOSITIONS AND RELATED METHODS DOW AGROSCIENCES LLC (US) 2015-04-30 WO disclosed
EP-2797915-A1 2 - BENZYL, 3 - (PYRIMIDIN- 2 -YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS Ironwood Pharmaceuticals, Inc. (US) 2014-11-05 EP disclosed
WO-2013101830-A1 2 - BENZYL, 3 - (PYRIMIDIN- 2 -YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2013-07-04 WO disclosed
EP-2588465-A1 SGC STIMULATORS Ironwood Pharmaceuticals, Inc. (US) 2013-05-08 EP disclosed
EP-2467137-A1 BIARYL COMPOUNDS AND METHODS OF USE THEREOF Ambit Biosciences Corporation (US) 2012-06-27 EP disclosed
WO-2012003405-A1 SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2012-01-05 WO disclosed
WO-2011022473-A1 BIARYL COMPOUNDS AND METHODS OF USE THEREOF AMBIT BIOSCIENCES CORPORATION (US) 2011-02-24 WO disclosed