Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | USP1 | O94782 | 1/20 | 0.30 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24855105 | 0.81 | — | — | |
| SCHEMBL24854497 | 0.76 | HRH3 (0.42) | — | |
| SCHEMBL17306142 | 0.75 | MAP3K12 (0.32) | MAP3K12 | |
| SCHEMBL25794606 | 0.74 | TLR9 (0.30) | — | |
| SCHEMBL15806952 | 0.73 | MAP3K12 (0.33) | MAP3K12 | |
| SCHEMBL25833417 | 0.72 | HRH3 (0.41) | — | |
| SCHEMBL24854339 | 0.71 | KAT2B (0.32) | MAP3K12 | |
| SCHEMBL22932478 | 0.71 | OPRL1 (0.39) | USP1WDR48 | |
| SCHEMBL24911020 | 0.70 | TSHR (0.33) | — | |
| SCHEMBL12424517 | 0.70 | USP1 (0.33) | MAP3K12USP1WDR48 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002382-A1 | SPIRO RING-CONTAINING QUINAZOLINE COMPOUNDS | Wigen Biomedicine Technology (shanghai) Co., Ltd. (CN) | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002382-A1 | SPIRO RING-CONTAINING QUINAZOLINE COMPOUNDS | KRAS, NRAS, HRAS | MAP3K12 332/4885USP1 2321/4885WDR48 938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.