Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.53 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | COMT | P21964 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435351 | 0.80 | TPMT (0.41) | KMT2AMEN1HTTPDK1 | |
| SCHEMBL8733117 | 0.79 | NPC1 (0.44) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8726017 | 0.79 | PDK1 (0.39) | KMT2AALDH1A1LMNASMN1; SMN2PDK1 | |
| SCHEMBL8731669 | 0.78 | GSK3B (0.38) | KMT2AMEN1SMN1; SMN2PDK1MAPT | |
| SCHEMBL7371022 | 0.77 | TDP1 (0.47) | TTRGPR35KMT2AMEN1ALDH1A1 | |
| SCHEMBL16884486 | 0.77 | TTR (0.67) | TTRABCC3ABCC4NR1I2ABCB11 | |
| SCHEMBL16884522 | 0.77 | TTR (0.67) | TTRABCC3ABCC4NR1I2ABCB11 | |
| SCHEMBL26997939 | 0.75 | TTR (0.69) | TTRABCC3ABCC4NR1I2ABCB11 | |
| SCHEMBL26997936 | 0.75 | TTR (0.69) | TTRABCC3ABCC4NR1I2ABCB11 | |
| SCHEMBL7373740 | 0.74 | TTR (0.71) | TTRABCC3ABCC4NR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278464-A1 | PHARMACOLOGICAL AGENTS FOR PREVENTING AND TREATING CATARACTS AND PRESBYOPIA EYE DISEASES | PLEX PHARMACEUTICALS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |