Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 11/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | FURIN | P09958 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453802 | 0.88 | S1PR1 (0.37) | S1PR1S1PR3S1PR4S1PR5SRC | |
| SCHEMBL2453805 | 0.88 | S1PR1 (0.37) | S1PR1S1PR3S1PR4S1PR5SRC | |
| SCHEMBL2453803 | 0.88 | S1PR1 (0.37) | S1PR1S1PR3S1PR4S1PR5SRC | |
| SCHEMBL2446646 | 0.82 | ENPP2 (0.36) | S1PR1S1PR3S1PR4S1PR5SRC | |
| SCHEMBL2457011 | 0.82 | ENPP2 (0.36) | S1PR1S1PR3S1PR4S1PR5SRC | |
| SCHEMBL2454808 | 0.79 | S1PR1 (0.37) | S1PR1S1PR3S1PR4S1PR5ABL1 | |
| SCHEMBL2454812 | 0.79 | S1PR1 (0.37) | S1PR1S1PR3S1PR4S1PR5ABL1 | |
| SCHEMBL2485792 | 0.78 | S1PR1 (0.42) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL2774941 | 0.78 | S1PR1 (0.42) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL2485801 | 0.78 | S1PR1 (0.42) | S1PR1S1PR3S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364088-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | Biogen Idec MA Inc. (US) | 2011-09-14 | — | — | EP | claimed |
| WO-2010051030-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | BIOGEN IDEC MA INC. (US) | 2010-05-06 | — | — | WO | claimed |