Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844546 | 0.87 | XDH (0.44) | XDHALDH1A1MAPTGABRA1GABRB2 | |
| SCHEMBL4693144 | 0.76 | MEN1 (0.31) | MEN1KMT2A | |
| SCHEMBL3259762 | 0.74 | XDH (0.58) | XDHALDH1A1MAPTGABRA1GABRB2 | |
| SCHEMBL7555913 | 0.72 | XDH (0.56) | XDHALDH1A1MAPTGABRA1GABRB2 | |
| SCHEMBL7266407 | 0.70 | XDH (0.42) | XDHALDH1A1MAPTGABRA1GABRB2 | |
| SCHEMBL7043823 | 0.70 | XDH (0.54) | XDHALDH1A1MAPTGABRA1GABRB2 | |
| SCHEMBL253471 | 0.70 | XDH (0.54) | XDHALDH1A1MAPTGABRA1GABRB2 | |
| SCHEMBL11494827 | 0.70 | XDH (0.54) | XDHALDH1A1MAPTGABRA1GABRB2 | |
| SCHEMBL198193 | 0.70 | XDH (0.54) | XDHALDH1A1MAPTGABRA1GABRB2 | |
| SCHEMBL7055734 | 0.70 | XDH (0.54) | XDHALDH1A1MAPTGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542238-A1 | COMPOUNDS FOR IMMUNOPROTEASOME INHIBITION | Onyx Therapeutics, Inc. (US) | 2013-01-09 | — | — | EP | claimed |
| WO-2011109355-A1 | COMPOUNDS FOR IMMUNOPROTEASOME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2011-09-09 | — | — | WO | claimed |
| EP-2041158-A2 | PEPTIDE EPOXYKETONES FOR PROTEASOME INHIBITION | Proteolix, Inc. (US) | 2009-04-01 | — | — | EP | claimed |
| WO-2007149512-A2 | PEPTIDE EPOXYKETONES FOR PR0TEAS0ME INHIBITION | PROTEOLIX, INC. (US) | 2007-12-27 | — | — | WO | claimed |
| EP-2207791-A1 | CRYSTALLINE PEPTIDE EPOXY KETONE PROTEASE INHIBITORS AND THE SYNTHESIS OF AMINO ACID KETO-EPOXIDES | Onyx Therapeutics, Inc. (US) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009045497-A1 | CRYSTALLINE PEPTIDE EPOXY KETONE PROTEASE INHIBITORS AND THE SYNTHESIS OF AMINO ACID KETO-EPOXIDES | PROTEOLIX, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2003101381-A2 | 1,2 DIAMIDO CYCLOALKYL SODIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2003-12-11 | — | — | WO | disclosed |