Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.72 |
| ▸ | EGFR | P00533 | 19/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18665661 | 0.84 | BTK (1.00) | BTKEGFR | |
| SCHEMBL21316378 | 0.83 | EGFR (0.79) | BTKEGFR | |
| SCHEMBL18665709 | 0.82 | EGFR (1.00) | BTKEGFR | |
| SCHEMBL18665651 | 0.82 | EGFR (1.00) | BTKEGFR | |
| SCHEMBL18665707 | 0.82 | EGFR (1.00) | BTKEGFR | |
| SCHEMBL18665700 | 0.79 | BTK (0.81) | BTKEGFR | |
| SCHEMBL18665600 | 0.79 | EGFR (1.00) | BTKEGFR | |
| SCHEMBL29617737 | 0.79 | EGFR (1.00) | BTKEGFR | |
| SCHEMBL24862190 | 0.78 | EGFR (0.68) | BTKEGFR | |
| SCHEMBL18665605 | 0.76 | EGFR (1.00) | BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4116303-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER | Loxo Oncology, Inc. (US) | 2023-01-11 | — | — | EP | disclosed |